Extracorporeal photopheresis therakos. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. Extracorporeal photopheresis may be considered medically necessary as a technique to treat early stage (I/II) cutaneous T-cell lymphoma that is progressive and refractory to established non-systemic therapies. 2 UVADEX ® (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOS ® CELLEX ® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. 1 THERAKOS performs ECP using patented technology that collects, separates and treats a small amount of white blood cells (immune cells) while the patient is connected to the instrument. Based on the substantial efficacy and the excellent safety profile in the The THERAKOS CELLEX Photopheresis System is the world's only fully integrated and validated ECP system. Nov 21, 2023 · Therakos UVAR XTS Operates on discontinuous cycle Single needle access Uses either 125 mL (small bowl) or 225 mL (Latham bowl) to collect mononuclear cells (3 - 6 cycles) Small bowl is used for pediatric patients, patients with anemia (HCT < 36%), lower body weight (< 45 kg) or hemodynamic instability Extracorporeal volume (ECV) ranges from 220 to 620 mL Typically takes ~4 hours to finish Learn about insurance coverage and financial assistance options for accessing THERAKOS® Photopheresis treatment for cutaneous T-cell lymphoma (CTCL) skin symptoms. S. The meaning of EXTRACORPOREAL is occurring or based outside the living body. THERAKOS Immunotherapy harnesses the power of each individual patient’s immune system to fight disease and is used by academic medical centres, hospitals, and treatment centres in more than 30 countries. THERAKOS™ CELLEX™ Photopheresis System The THERAKOS™ CELLEX™ Photopheresis System has received CE Certification under the European Union Medical Device Regulation (EU MDR) Feb 21, 2024 · Mallinckrodt Presents Data on Real-World Outcomes with THERAKOS™ CELLEX™ Photopheresis System Treatment at the 2024 Tandem Meetings – Analysis of published studies of extracorporeal photopheresis (ECP) treatment for steroid-refractory chronic graft-versus-host disease (SR-cGvHD) assessed that THERAKOS ECP can improve short- and long-term patient outcomes1 – THIS INFORMATION IS INTENDED Our video guide to ECP details everything you need to know about Extracorporeal Photopheresis treatment. For over 30 years, Therakos have pioneered advancements in immunomodulatory therapy technology via extracorporeal photopheresis (ECP). Nov 2, 2023 · A Novel, Closed-Line Mini Extracorporeal Photopheresis (ECP) Technique Using the Therakos TM CellEx TM Photopheresis System, Developed for Patients with Contraindications Against Conventional ECP Therapy THERAKOS CELLEX Photopheresis focuses on the delivery of extracorporeal photopheresis (ECP) immunomodulation. From preparation to aftercare. ECMO keeps blood moving through the body and keeps blood gasses (oxygen and carbon dioxide) in balance. THERAKOS® CELLEX® Photopheresis System THERAKOS® CELLEX® delivers a fully integrated, automated extracorporeal photopheresis (ECP) system, providing superior efficiency, safety, and patient outcomes. In this method, all the phases (leukapheresis, photoactivation, reinfusion) are achieved sequentially in extracorporeal circulation using a single instrument. Only health care professionals with training in THERAKOS Photopheresis should administer this therapy. Sep 14, 2025 · Extracorporeal membrane oxygenation is used for cardiac or respiratory failure where conventional management, including cardiopulmonary resuscitation, is not successful. Extracorporeal membrane oxygenation (ECMO) is a form of extracorporeal life support, providing prolonged cardiac and respiratory support to people whose heart and lungs are unable to provide an adequate amount of oxygen, gas exchange or blood supply (perfusion) to sustain life. Dec 2, 2024 · The investment in Therakos from CVC Capital Partners Fund IX will provide the resources and expertise to further develop the business and its services which improve the lives of patients. Aug 12, 2016 · THERAKOS ECP Immunomodulation is delivered through the CELLEX and UVAR XTS ® extracorporeal photopheresis (ECP) systems. What is Therakos ECP Immunomodulation™? Extracorporeal photopheresis (ECP) Extracorporeal photopheresis (ECP) is an immunomodulatory therapy that has demonstrated efficacy in various T-cell and immune-mediated diseases. , Canada, Europe, Japan, Australia and Latin America, it is the platform-of-choice among healthcare providers and patients to treat a range of immune-related diseases. The exact way that THERAKOS Photopheresis works is not known. ECMO does not treat lung or heart failure, but does the jobs of the heart and lungs temporarily ― allowing them to “rest. Jan 27, 2021 · ABOUT THE THERAKOS CELLEX ECP SYSTEM The CELLEX System delivers extracorporeal photopheresis (ECP), and consists of an instrument, procedural kit, methoxsalen solution and a UVA lamp. . See Apheresis. Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Explore our history. THERAKOS Photopheresis treatments should always be performed in locations where standard medical emergency equipment is available. Our THERAKOS™ CELLEX™ Photopheresis System delivers extracorporeal photopheresis (also known as ECP*), a treatment for patients with a range of immune-mediated diseases We have been developing this treatment and advancing the technology of our THERAKOS™ CELLEX™ Photopheresis System for over 30 years Review the clinical profile of THERAKOS® Photopheresis, including efficacy data and patient experiences in managing Cutaneous T-Cell Lymphoma (CTCL) skin manifestations. ” It uses a machine outside the body (extracorporeal). The “on-line” method can be performed on either the Therakos UVAR XTS or the Therakos CELLEX Photoapheresis System (Therakos, Raritan, NJ, USA). 3 Wepsięć K, et al. Therakos is the leading company in Extracorporeal Photopheresis (ECP) delivery systems for autologous immunomodulatory therapy. Concomitant Therapy: When prescribing and administering THERAKOS Photopheresis for patients receiving concomitant therapy, exercise caution when changing treatment schedules to avoid increased disease activity that may be caused by abrupt withdrawal of previous therapy. * THERAKOS Photopheresis was first approved by the FDA in 1987 for the palliative treatment of CTCL skin symptoms in patients who were not responsive to other types of treatment. Through these collaborations, we aim to build a better future for patients. How to use extracorporeal in a sentence. 1 Unlike immunosuppressive therapies, ECP has not been associated with an increased incidence of infections. Aug 7, 2023 · What does ECMO stand for? ECMO stands for extracorporeal membrane oxygenation. Volume replacement fluids and/or volume expanders should be readily available throughout the procedure. The exact way ECP works is unknown. UVADEX ® (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOS ® CELLEX ® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. Our systems are used by academic medical centers, hospitals, and treatment centers in more than 30 countries and have already delivered over Scarisbrick JJ, Taylor P, Holtick U, on behalf of the Photopheresis Expert Group U. The THERAKOS™ CELLEX™ Photopheresis System is the world’s only fully integrated validated ECP system. Key advantages: Faster treatment times (1): Single-needle mode: 105 mins/Treatment Double-needle mode: 75 mins/Treatment Only Online, integrated device to be approved by both FDA and EU THERAKOS Photopheresis treatments should always be performed in locations where standard medical emergency equipment is available. Therakos therapeutic platforms, including the latest generation THERAKOS® CELLEX® Photopheresis System, are the world’s only approved fully-integrated systems for administering autologous immune cell therapy through Extracorporeal Photopheresis (ECP). An extracorporeal procedure is a medical procedure which is performed outside the body. INDICATION UVADEXTM (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOS® CELLEX® Photopheresis Systems in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. Extracorporeal photopheresis may be considered medically necessary as a technique to treat late-stage (III/IV) cutaneous T-cell lymphoma. Therakos ECP Immunomodulation Understanding THERAKOS@ Extracorporeal Photopheresis (ECP) Harnessing the power of your immune system to fight disease Information for patients Mallinckrodt Pharmaceuticals Your doctor has recommended that you have photopheresis (pronounced foh-toh-fuh-ree-sis) to treat your condition. This therapy is believed to work by harnessing the power of your own immune system, acting from inside your body to treat CTCL skin symptoms. Discover its functionalities with our 3D experience. It is used to treat a range of immune-mediated diseases. Get help understanding your benefits and download a decision aid to discuss this therapy with your healthcare team. The objective of this retrospective study was to compare the new Amicus Blue inline system with the Therakos Cellex Explore the THERAKOS® CELLEX® Photopheresis System, an FDA-approved ECP therapy for Cutaneous T-Cell Lymphoma (CTCL) skin manifestations unresponsive to other treatments. Extracorporeal devices are the artificial organs that remain outside the body while treating a patient. Learn how this innovative therapy harnesses your immune system, what to expect during the CELLEX treatment, when you may see results, and questions to ask your doctor about using your own cells to treat CTCL from the inside out. 3 Therakos is an established, guideline-recommended therapy for indicated immune-mediated conditions2-10 Therakos is used by more than 300 treatment centers in over 30 countries1 The Therakos Photopheresis system is available in tertiary care centres across Canada1 Therakos Photopheresis average treatment are less than 2 hours:11 How does ECP work? See how Extracorporeal Photopheresis (ECP) harnesses the power of the immune system and works in the THERAKOS™ CELLEX™ procedural video. We would like to show you a description here but the site won’t allow us. Find the guide here The THERAKOS ® Photopheresis System is an immunomodulatory therapy that uses extracorporeal photopheresis (ECP) to help enhance immunologic response. “Extracorporeal” means outside of your body. The machine removes carbon dioxide and sends oxygen-rich blood back to the body. After the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma was published in 1983 with its subsequent recognition by the FDA for its refractory forms, the technology has shown UVADEX ® (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOS ® CELLEX ® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. With approvals for use in the U. Explore the THERAKOS® CELLEX® Photopheresis System, an FDA-approved ECP therapy for Cutaneous T-Cell Lymphoma (CTCL) skin manifestations unresponsive to other treatments. Sep 5, 2025 · At the Therakos Institute, our primary goal is to advance knowledge and understanding around Extracorporeal Photopheresis (ECP) immunomodulation. extracorporeal adjective Referring to circulation of blood that occurs outside the body–eg, via apheresis. Extracorporeal means "outside of the body. Oct 11, 2024 · ECMO is a form of life support if you have serious lung or heart failure, injuries, or the heart or lungs are too weak to work properly. 1 An online version An extracorporeal procedure is a medical procedure which is performed outside the body. Jul 3, 2024 · Extracorporeal photopheresis in acute graft versus host disease Acute GVHD is a major, life-threatening complication of allo-HCT. An ECMO machine constantly pumps blood out of your body and then sends it through devices that add oxygen and remove carbon dioxide. It then pumps the blood back into your body. UVADEX ® (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOS ® CELLEX ® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. Jun 15, 2024 · In extracorporeal membrane oxygenation (ECMO), blood is pumped outside of the body to a heart-lung machine. It can help you when your lungs and heart aren’t functioning correctly. Download a full directory of facilities offering extracorporeal photopheresis. [19] The instrument separates and collects the lymphomonocyte fraction (buffy coat THERAKOS Photopheresis is an extracorporeal photopheresis (ECP) treatment used by people whose CTCL skin symptoms have not responded to other types of treatments. 1,2 Since launch over 35 years ago, there have been over 1. Jun 13, 2023 · DUBLIN, /PRNewswire/ — Mallinckrodt plc (NYSE American: MNK), a global specialty pharmaceutical company, today announced the publication of findings from a retrospective, observational, single arm, European chart review study assessing the real-world use of extracorporeal photopheresis (ECP) and its impact on clinical outcomes in the modern era of heart transplantation. ECP stands for extracorporeal photopheresis – a light-activated treatment performed on temporarily separated blood cells outside the body. Cost-effectiveness analysis of extracorporeal photopheresis (procedure Therakos™) in the treatment of steroid-refractory graft versus host disease. We have forged valuable partnerships with leading experts from around the world, regularly bringing our best and brightest together to provide accessible education to HCPs. Thromboembolic Events: Thromboembolic events, including pulmonary embolism and deep vein thrombosis, have been reported in the treatment of GvHD, an indication Access free downloadable CTCL resources including a decision aid for THERAKOS® Photopheresis treatment,a getting started action plan, treatment center directory, living with CTCL discussion guide, and more. Aug 5, 2024 · Therakos is a fully integrated extracorporeal photopheresis (ECP) delivery system for autologous immunomodulatory therapy. INDICATION: The THERAKOSTM CELLEXTM Photopheresis System is used for the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma (CTCL) and systemic sclerosis (SSc). " A membrane oxygenator puts oxygen in the blood and removes carbon dioxide. Background/Objectives: Extracorporeal photopheresis (ECP) is a well-established and efficacious cell therapy for a range of diseases. The THERAKOS ® Photopheresis System is an immunomodulatory therapy that uses extracorporeal photopheresis (ECP) to help enhance immunologic response. Oct 6, 2024 · The extracorporeal circuit allows for the oxygenation and removal of carbon dioxide from blood used as a supportive strategy in patients who have a high risk of death despite conventional therapy Jul 17, 2025 · What is ECMO? ECMO (extracorporeal membrane oxygenation) is a type of artificial life support. Locate THERAKOS® photopheresis treatment centers close to you. K. Extracorporeal photopheresis THERAKOS® Photopheresis is an extracorporeal photopheresis (ECP) treatment for Cutaneous T-Cell Lymphoma (CTCL) skin symptoms unresponsive to other therapies. THERAKOS ECP EDGE IS A COMPREHENSIVE RANGE OF PRODUCT SUPPORT SERVICES TO HELP HEALTHCARE PROFESSIONALS (HCPs) DELIVER OPTIMIZED EXTRACORPOREAL PHOTOPHERESIS (ECP) IMMUNOMODULATION TO PATIENTS. Jul 17, 2025 · What is ECMO? ECMO (extracorporeal membrane oxygenation) is a type of artificial life support. THERAKOS CELLEX Photopheresis has shown efficacy in patients with skin manifestations of cutaneous T-cell lymphoma and systemic sclerosis. cy zroc p4nq aj v5mwd u9 60s oig5p en 1wp