Saima riazuddin lab. As an example, mutations found commonly among the deaf Jun 14, 2013 · Objective To identify the genetic cause of prelingual sensorineural hearing loss in Pakistani families using a next-generation sequencing (NGS)–based mutation s Jun 14, 2013 · Objective To identify the genetic cause of prelingual sensorineural hearing loss in Pakistani families using a next-generation sequencing (NGS)–based mutation s Authors Amama Ghaffar 1 2 , Faiza Rasheed 2 , Muhammad Rashid 2 , Hans van Bokhoven 3 , Zubair M Ahmed 1 4 , Sheikh Riazuddin 5 , Saima Riazuddin 6 7 Jun 14, 2013 · Objective To identify the genetic cause of prelingual sensorineural hearing loss in Pakistani families using a next-generation sequencing (NGS)–based mutation s Authors Saima Riazuddin 1 , Saima Anwar, Martin Fischer, Zubair M Ahmed, Shahid Y Khan, Audrey G H Janssen, Ahmad U Zafar, Ute Scholl, Tayyab Husnain, Inna A Belyantseva, Penelope L Friedman, Sheikh Riazuddin, Thomas B Friedman, Christoph Fahlke Jun 14, 2013 · Objective To identify the genetic cause of prelingual sensorineural hearing loss in Pakistani families using a next-generation sequencing (NGS)–based mutation s Authors Amama Ghaffar 1 2 , Faiza Rasheed 2 , Muhammad Rashid 2 , Hans van Bokhoven 3 , Zubair M Ahmed 1 4 , Sheikh Riazuddin 5 , Saima Riazuddin 6 7 Name: Dr. The results of her reserach are pulished in Nature genetics, Cell, Journal of Clinical Investigtation, PLoS genetics and Molecular Psychiatry. Release Year: 2013. Saima Riazuddin, PhD, MPH, MBA, Professor of Otorhinolaryngology and Biochemistry, and Co-Director for Academic Development in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine, is one of the primary investigators on this study. Our ultimate goal is to identify targets for therapeutic interventions. edu; Saima Riazuddin, Laboratory of Molecular Genetics, Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD, 21201. In this study we have shown the functional consequeces of p. Ahmed Jun 28, 2006 · Sound and acceleration are detected by hair bundles, mechanosensory structures located at the apical pole of hair cells in the inner ear. One of these links, the tip link, conn … Sep 7, 2025 · Inner Ear Development and Hearing Loss, Hardcover by Riazuddin, Saima (EDT); Ahmed, Zubair (EDT), ISBN 1624170110, ISBN-13 9781624170119, Like New Used, Free shipping in the US Authors Saima Riazuddin 1 , Shaheen N Khan, Zubair M Ahmed, Manju Ghosh, Kyle Caution, Sabiha Nazli, Madhulika Kabra, Ahmad U Zafar, Kevin Chen, Sadaf Naz, Anthony Antonellis, William J Pavan, Eric D Green, Edward R Wilcox, Penelope L Friedman, Robert J Morell, Sheikh Riazuddin, Thomas B Friedman. The cEAR is a collaborative clinical and research consortium led by Zubair Ahmed, PhD, Saima Riazuddin, PhD and Ronna Hertzano MD, PhD. Saima Riazuddin, an adjunct faculty in Molecular Biology at the Shaheed Zulfiqar Ali Bhutto Oct 25, 2025 · KLHL13 functional defects cause neurodevelopmental disorder in humans that can be rescued via inhibition of AURKB in cellular and animal models Tehmeena Akhter, Zubair M. Dr Riazuddin's scientific accomplishments have earned Saima Riazuddin 1 2 3 4 , Inna A Belyantseva 5 , Arnaud P J Giese 1 2 , Kwanghyuk Lee 6 , Artur A Indzhykulian 7 , Sri Pratima Nandamuri 8 , Rizwan Yousaf 1 9 , Ghanshyam P Sinha 7 , Sue Lee 5 , David Terrell 2 , Rashmi S Hegde 10 , Rana A Ali 9 , Saima Anwar 9 , Paula B Andrade-Elizondo 6 , Asli Sirmaci 11 , Leslie V Parise 12 , Sulman Basit Saima Riazuddin, PhD Riazuddin’s lab continued to investigate the molecular and genetic basis of hearing loss, utilizing human and mouse genetics. , Room 404, Baltimore, Maryland, 21201. edu Name: Dr. Riazuddin on ScienceDirect, the world's leading source for scientific, technical, and medical research. Saima Riazuddin is investigating the molecular and genetic basis of hearing loss and deaf-blindness (Usher syndrome), utilizing human and mouse genetics. Riazuddin’s laboratory is investigating the genetic factors associated with hearing impairment and understanding the precise mechanism of various forms of hearing dysfunction using human pedigrees, mutant mouse models and zebrafish as tools. Abstract Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Sep 9, 2016 · The research team was led in part by principal investigator Saima Riazuddin, PhD, MPH, MBA, professor of Otorhinolaryngology Head & Neck Surgery and professor of Biochemistry & Molecular Biology at the University of Maryland School of Medicine (UMSOM). Jul 1, 2021 · Adaptor protein (AP) complexes mediate selective intracellular vesicular trafficking and polarized localization of somatodendritic proteins in neurons. Morell, 1 Thomas B. Saima Riazuddin, PhD Riazuddin’s lab continued to investigate the molecular and genetic basis of hearing loss, utilizing human and mouse genetics. Saima Riazuddin, PhD Dr. Mar 20, 2023 · Congenital hearing impairment (HI) is a genetically highly heterogeneous disorder in which prompt recognition and intervention are crucial to optimize outcomes. We built a compact database, … Authors Saima Riazuddin 1 , Sabiha Nazli, Zubair M Ahmed, Yi Yang, Fareeha Zulfiqar, Rehan S Shaikh, Ahmed U Zafar, Shaheen N Khan, Farooq Sabar, Fouzia T Javid, Edward R Wilcox, Ekaterini Tsilou, Erich T Boger, James R Sellers, Inna A Belyantseva, Sheikh Riazuddin, Thomas B Friedman Authors Nevra Nal 1 , Zubair M Ahmed, Engin Erkal, Ozgül M Alper, Güven Lüleci, Oktay Dinç, Ali Muhammad Waryah, Quratul Ain, Saba Tasneem, Tayyab Husnain, Parna Chattaraj, Saima Riazuddin, Erich Boger, Manju Ghosh, Madhulika Kabra, Sheikh Riazuddin, Robert J Morell, Thomas B Friedman Mar 16, 2023 · The genetic etiologies of more than half of rare diseases remain unknown. Fertig, PhD Programs: Molecular Medicine Research/Clinical Keywords: predictive medicine, tumor immunotherapy, computational oncology, chaos theory, molecular profile technologies Lab Website: The Fertig Lab Apr 3, 2025 · Summary: Our study reveals that CIB2 is a multifunctional protein with key independent functions in the development of the stereocilia staircase pattern in mouse auditory hair cells. Using the zebrafish and mouse models, she is attempting to identify and characterize the genes responsible for inherited human neurodevelopmental disorders, particularly intellectual disabilities. Ahmed,1,3 Saima Riazuddin,1,3 Steve L. Lalwani, Mary Ann Mastroianni, Sadaf Naz, Tenesha N. Ahmed Designation: Visiting Teacher in PU Jul 11, 2014 · Saima Riazuddin University of Maryland, School of Medicine, USA Designation: Editorial Board Orcid: Jul 1, 2018 · Genetics and Functional Studies of Autosomal Recessive Neurological Disorders Riazuddin, Saima University of Maryland Baltimore, Baltimore, MD, United States Abstract According to WHO estimates, neurological conditions account for over 6% of the global disease burden. Release Date: 03/05/2013. Address correspondence to: Saima Riazuddin, Laboratory of Molecular Genetics, Cincinnati Children’s Hospital Research Foundation, 3333 Burnet Avenue, MLC2018, Cincinnati, Ohio 45229, USA. Dr. Genomic DNA from an affected member of a consanguineous family segregating recessive, View Saima Riazuddin’s profile on LinkedIn, a professional community of 1 billion members. Bernstein,4 Zahoor Ahmed,3 Shaheen Khan,3 Andrew J. Saima Riazuddin's 164 research works with 7,516 citations and 18,822 reads, including: Dual AAV based PCDH15 gene therapy achieves sustained rescue of visual function in a mouse model of Read articles by Saima A. Here, we refine the interacting domains between these proteins and provide evidence that both proteins have distinct role in the , Saima Riazuddin, PhD 124 Saima Riazuddin Divisions of Ophthalmology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio USA Human Genetics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, USA National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan 15 Department of Pharmaceutical and Pharmacological Sciences, Lab of Cell Metabolism, University of Leuven, Leuven, Belgium. Learn more Saima Riazuddin is 50 years old today because Saima's birthday is on 11/30/1974. Ahmed 3,6,7,* Sep 7, 2016 · Islamabad On the basis of her outstanding work in hearing impairment and cognitive disabilities, Dr. Although several studies provided evidence of genetics playing a significant role in the Mar 10, 2008 · Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Room 2A-19, Rockville, MD, 20850 Mar 28, 2018 · Laboratory of Molecular Genetics, Department of Otorhinolaryngology-Head & Neck Surgery, School of Medicine University of Maryland, Baltimore, MD, United States of America. Taylor, Sheikh Riazuddin, Saima Riazuddin The genetic etiologies of more than half of rare diseases remain unknown. She utilizes, human genetics, mouse and zebrafish model systems to identify genes responsible for various inherited disorders in human. Item Height: 260mm. Jul 31, 2024 · Variations in genes coding for calcium and integrin binding protein 2 (CIB2) and whirlin cause deafness both in humans and mice. Discover recipes, home ideas, style inspiration and other ideas to try. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies, but this depends on efficient and Lab Website: The Ferrer Lab at the University of Maryland Baltimore and the Greenebaum Comprehensive Cancer Center Elana J. Amer Riazuddin, Shahbaz Ali, Tahir Farooq, Zaheeruddin A. edu. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure and function of tricellular contacts of Dr. The auditory genetics lab of Saima Riazuddin, PhD, made large strides toward unlocking the mystery of hereditary deafness. We previously reported that CIB2 binds to whirlin, and is essential for normal staircase architecture of auditory hair cells stereocilia. Format: Hardback. Castelein, Zubair M. Her research has been publishe in highly ranked scientific journals. Parise, Sulman Basit, Abdul Wali, Muhammad Ayub, Muhammad Ansar, Wasim Ahmad Nov 9, 2021 · A preclinical study using exogenous retinoids in a novel Usher syndrome 1F mouse model reveals a possible therapy to treat mutant PCDH15-mediated visual dysfunction. Mar 3, 2010 · Targeted genome capture combined with next-generation sequencing was used to analyze 2. Khan, Tayyab Husnain, Saima Riazuddin, Paul A. CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture Arnaud P. Riazuddin’s team is focused on understanding the molecular and genetic basis of hearing impairment. Friedman, Andrew J. Our labs are dedicated to discovering and functionally characterizing molecular factors associated with hereditary disorders of the Brain, Inner ear, and Retina. Andrade-Elizondo, Asli Sirmaci, Leslie V. 9 Mb of the DFNB79 interval on chromosome 9q34. In April 2022, she joined Dr. Griffith, Sheikh Riazuddin CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture Arnaud P. Zubair M. Ahmed, Yaping Ji, Rodney J. Riazuddin is the principal investigator of two NIH R01 grants and multiple other national and international grants. Her lab recently identified the MSRB3 gene that is responsible for autosomal recessively inherited deafness (DFNB74) in eight Pakistani families. TRIC encodes tricellulin, a recently discovered tight-juncti … Nov 8, 2021 · Funding This work was supported by National Institute of Neurological Disorders and Stroke, National Institutes of Health grant R01NS107428 to Saima Riazuddin. 3798; Email: sriazuddin@som. Sieving, J. Authors Saima Riazuddin 1 , Zubair M Ahmed, Thomas B Friedman, Andrew J Griffith, Sheikh Riazuddin, Edward R Wilcox Articles by Saima Riazuddin on Muck Rack. Bowl, Zubair M. I12T differ from BSND mutations that cause renal failure and deafness in Bartter syndrome. Liburd, Thomas B. Belyantseva, Arnaud Giese, Kwanghyuk Lee, Artur A. Vander Kooi, Michael R. Fielding Hejtmancik, Sheikh Riazuddin. The focus of Dr. 301 Moved Permanently301 Moved Permanently cloudflare Oct 20, 2023 · Authors Sehar Riaz 1 , Saumil Sethna 2 , Todd Duncan 3 , Muhammad A Naeem 4 , T Michael Redmond 3 , Sheikh Riazuddin 5 , Saima Riazuddin 6 , Livia S Carvalho 7 , Zubair M Ahmed 8 Aug 26, 2025 · Saima Riazuddin, Tiffany Cook & Zubair M. Friedman, 1 Sheikh Riazuddin, 3 and Edward R. Ahmed, 1,3 Saima Riazuddin, 1,3 Steve L. Riazuddin’s Lab as a graduate research fellow. Other names that Saima uses includes Saima Riazuddin Ahmed and Saima Raizuddin. Griffith, 1,2 Robert J. Saima Riazuddin, PhD, MPH, MBA Professor at the University of Genetics of Hearing Disorders (Go-HEAR) research program in Dr. umaryland. Morell,1 Thomas B. 3, which includes 108 candidate genes. One of these links, the tip link, conn … Aug 13, 2025 · Author: Saima Riazuddin. Saima Riazuddin lives in Ellicott City, MD; previous city include Boyds MD. Sinha, Sue Lee, David Terrell, Rashmi S. Pathogenic mutations in TULP1 are associated with Retinitis pigmentosa in consanguineous Pakistani families. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies, but this depends on efficient and powerful The genetic etiologies of more than half of rare diseases remain unknown. However, knowledge on how genes affect hearing remain inadequate. In this study, we utilized genome-wide genotyping, Sanger and exome sequencing to identify 163 DNA … Email: sleal@bcm. Saima Riazuddin During FY09, Dr. Saima Riazuddin, Caley M. Selected Publications: Muhammad Iqbal, Muhammad Asif Naeem, S. Kiyoto Kurima 1 , Linda M Peters, Yandan Yang, Saima Riazuddin, Zubair M Ahmed, Sadaf Naz, Deidre Arnaud, Stacy Drury, Jianhong Mo, Tomoko Makishima, Manju Ghosh, P S N Menon, Dilip Deshmukh, Carole Oddoux, Harry Ostrer, Shaheen Khan, Sheikh Riazuddin, Prescott L Deininger, Lori L Hampton, Susan L Sullivan, James F Battey Jr, Bronya J B Keats Dec 15, 2003 · Zubair M Ahmed 1 , Saima Riazuddin, Jamil Ahmad, Steve L Bernstein, Yan Guo, Muhammad F Sabar, Paul Sieving, Sheikh Riazuddin, Andrew J Griffith, Thomas B Friedman, Inna A Belyantseva, Edward R Wilcox Sep 30, 2021 · Priya Jarwar, 1,2 Shakeel Ahmed Sheikh, 2,3 Yar Muhammad Waryah, 4 Ikram Uddin Ujjan, 5 Saima Riazuddin, 2,6 Ali Muhammad Waryah, 2,* and Zubair M. Missing Information?. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies, but this depends on efficient and powerful analytical methods. Saima Riazuddin is currently working as an associate Professor of Otolaryngology-Head & Neck Surgery at University of Maryland, United states. Riazuddin's lab is engaged in inner ear and brain research. The different elements of the hair bundle, the stereocilia and a kinocilium, are interconnected by a variety of link types. Zubair M Ahmed 1 , Saber Masmoudi, Ersan Kalay, Inna A Belyantseva, Mohamed Ali Mosrati, Rob W J Collin, Saima Riazuddin, Mounira Hmani-Aifa, Hanka Venselaar, Mayya N Kawar, Abdelaziz Tlili, Bert van der Zwaag, Shahid Y Khan, Leila Ayadi, S Amer Riazuddin, Robert J Morell, Andrew J Griffith, Ilhem Charfedine, Refik Caylan, Jaap Oostrik, Ahmet Authors Zubair M Ahmed 1 , Saima Riazuddin, Thomas B Friedman, Sheikh Riazuddin, Edward R Wilcox, Andrew J Griffith The auditory genetics lab of Saima Riazuddin, PhD, made large strides toward unlocking the mystery of hereditary deafness. Saima Riazuddin Designation: Visiting Teacher in PU Professor Department of Otorhinolaryngology Head & Neck Surgery University of Maryland, School of Medicine BioParkBldg 1, 800 West Baltimore St, Room 404, Baltimore, MD, 21201, USA. Her lab recently identified the ELMOD3 gene that is responsible for autosomal recessively inherited deafness (DFNB88). In this study, we used exome sequencing to investigate a large consanguineous Pakistani family with eight affected individuals showing bila … Authors Zubair M Ahmed 1 , Saima Riazuddin, Sandar Aye, Rana A Ali, Hanka Venselaar, Saima Anwar, Polina P Belyantseva, Muhammad Qasim, Sheikh Riazuddin, Thomas B Friedman Oct 26, 2008 · Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans Zubair M Ahmed, 1,13 Saber Masmoudi, 2,13 Ersan Kalay, 3,4,5,13 Inna A Belyantseva, 1 Mohamed Ali Mosrati, 2 Rob W J Collin, 3,4 Saima Riazuddin, 1 Mounira Hmani-Aifa, 2 Hanka Venselaar, 6 Mayya N Kawar, 1 Tlili Abdelaziz, 2 Bert van der Zwaag, 7 Shahid Y Khan, 8 Leila Ayadi, 2 S Amer May 1, 2001 · Inheritance of a deafness-causing genotype does not necessarily mean that a person will have profound hearing loss. M. Country/Region of Manufacture: US. Our collaborative investigators employ these approaches and a variety of models and techniques to understand neural form, function, modulation, and disorder. Rutter, MD, Associate Professor , Saima Riazuddin, PhD 124 Saima Riazuddin Divisions of Ophthalmology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio USA Human Genetics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, USA National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Aug 1, 2025 · Authors Gowri Nayak 1 , Elodie M Richard 2 , Byung Cheon Lee 3 4 5 , Gavin P Riordan 6 , Inna A Belyantseva 6 , Bruno Manta 3 5 , Thomas B Friedman 6 , Vadim N Gladyshev 3 5 , Saima Riazuddin 2 7 15 Department of Pharmaceutical and Pharmacological Sciences, Lab of Cell Metabolism, University of Leuven, Leuven, Belgium. Apr 24, 2021 · Identification of Hearing Loss-Associated Variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani Families Umair Mahmood, 1 Shazia A. Qazi, Shaheen N. Wilcox 1 Sep 8, 2016 · The research team was led in in part by Principal Investigator Saima Riazuddin, PhD, MPH, MBA Professor of Otorhinolaryngology Head & Neck Surgery and Professor of Biochemistry & Molecular Biology Consanguineous Pakistani pedigrees segregating deafness have contributed decisively to the discovery of 31 of the 68 genes associated with nonsyndromic autosomal recessive hearing loss (HL) worldwide. Ahmed, Anil K. Find Saima Riazuddin's email address, contact information, LinkedIn, Twitter, other social media and more. riazuddin@jhmi. J. The presence of a modifying gene can change the effect of the deafness genotype. Get the details of Saima Riazuddin's business profile including email address, phone number, work history and more. Saima Riazuddin, Inna A. Mutations of the Protocadherin Gene PCDH15 Cause Usher Syndrome Type 1F Zubair M. Saima Riazuddin’s lab is designed to identify and characterize proteins essential to human inner ear development, neurosensory function and long-term maintenance. Saima Riazuddin, PhD Cincinnati Children’s Hospital Medical Center, Ohio “Generation and characterization of a mouse model of DFNB26” More than 100 gene locations have been indentified as contributing to hearing loss in its various forms. 3 Synthetic Protein Engineering Lab (SPEL), Department of Molecular Science and Technology, Ajou University, Suwon, South Saima Riazuddin 1 Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, 20850, USA. Hegde, Rana A. Friedman,1 Sheikh Riazuddin,3 and Edward R. 16 The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore MD, USA. Address correspondence to: Saima Riazuddin, Laboratory of Molecular Genetics, Department of Otorhinolaryngology – Head and Neck Surgery, University of Maryland School of Medicine, 800 West Baltimore St. Email: sriazuddin@smail. Disease-causing alleles of various subunits of AP complexes have been implicated in several heritable human disorders, including intellectual disabi … Affiliations 1 Center for Statistical Genetics, Gertrude H. Ahmed Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA View Saima Riazuddin’s profile on LinkedIn, a professional community of 1 billion members. Jun 23, 2021 · Genetic cause of neurodevelopmental disorder discovered Date: June 23, 2021 Source: University of Maryland School of Medicine Summary: Researchers identified a new gene that may be linked to Jun 7, 2001 · Zubair M. Bukhari, 1 Muhammad Ali, 2 Zubair M. Ahmed, 3 and Saima Riazuddin 3 On neurodevelopmental disorders we collaborate with the groups of Saima Riazuddin and Zubair Ahmed who have used human genetics of isolated populations to discovered a host of new recessive gene mutations leading to sever disorders of brain development, which we can examine molecularly in the embryonic mouse brain. The identified mutations are further studied by analyzing the orthologous mutant mouse models, which The inner ear has fluid-filled compartments of different ionic compositions, including the endolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical procedures necessary for its management. Bernstein, 4 Zahoor Ahmed, 3 Shaheen Khan, 3 Andrew J. BSND has been reported as a disease gene for a severe variant of barter syndrome that combines renal salt loss with sensorineural deafness. Griffith,1,2 Robert J. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY, USA. Smith, Nikki A. Riazuddin characterized a nonsyndromic deafness gene known as BSND. 736. Collectively they have published over 200 manuscripts in peer reviewed journals, cited over 14,500 times, and contributed in the identification and/or characterization of 28 of the currently known deafness genes. Brown, Saima Riazuddin, Craig W. Wilcox1 Mar 13, 2009 · Saima Riazuddin, Zubair M Ahmed & Thomas B Friedman Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA Biallelic in-frame deletion of SOX4 is associated with developmental delay, hypotonia and intellectual disability Article Nov 2021 Amama Ghaffar Faiza Rasheed Muhammad Rashid [] Saima Riazuddin The inner ear has fluid-filled compartments of different ionic compositions, including the endolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. Indzhykulian, Sri Pratima Nandamuri, Rizwan Yousaf, Ghanshyam P. Giese, Andrew Parker, Sakina Rehman, Steve D. Ali, Saima Anwar, Paula B. Myer III, MD, Professor ; Director, Pediatric Otolaryngology Residency Program Saima Riazuddin, PhD, Assistant Professor ; Director, Laboratory of Molecular Genetics Michael J. Phone: 410. This is done by ascertaining large human families segregating hearing loss and through genetic screening; disease causing mutations are identified in these families. Jan 7, 2011 · Affiliation 1 Laboratory of Molecular Genetics, Division of Pediatric Otolaryngology Head & Neck Surgery, Cincinnati Children's Hospital Research Foundation, and the Department of Otolaryngology, College of Medicine, University of Cincinnati, OH, 45229 USA. The studies under investigation are designed to answer the following broad questions: What are the precise mechanisms of various forms of hearing dysfunction? Research Focus Groups Our neuroscience research faculty conduct basic, clinical, and translational research to study the nervous system at the cellular and molecular, systems and circuits, and cognitive and behavioral levels. 2 Department of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, Baltimore, MD, USA. At the University of Maryland Medical Center (UMMC), Saima Riazuddin, PhD, MPH, MBA, Professor of Otorhinolaryngology and Biochemistry, leads a lab dedicated to inner ear and brain research. Riazuddin’s lab continued to investigate the molecular and genetic basis of hearing loss, utilizing human and mouse genetics. Charles M. ge lce qn dkurbg 3gooh q70zr br nv3 3u9r cgt8